AHH / Animal Diseases / Animal Health / Article / Epidemiology / ILRI / ILRI40 / LiveGene / LIVESTOCK-FISH / Research / Vaccines

ILRI initiative seeks new-generation vaccines against major livestock diseases

This poster explains the work of the Vaccine Biosciences group at the International Livestock Research Institute (ILRI) which seeks to a hub of research excellence dedicated to developing vaccine-based solutions to reduce disease burdens that limit livestock productivity in smallholder and pastoral farming systems. Continue reading

AHH / Disease Control / ECF / Kenya / Research / Vaccines

East Coast fever vaccine national distribution launch

‘For four decades, the Nairobi-based International Livestock Research Institute (ILRI) and its predecessor (the International Laboratory for Research on Animal Diseases, ILRAD) have conducted research on the lethal tick-borne cattle disease known as East Coast fever. ILRI’s work has focused on developing a new-generation ‘subunit’ vaccine, comprising molecular components of the causative parasite, while also … Continue reading

AHH / Animal Diseases / ECF / Project / Research / Vaccines

Designing bovine T cell vaccines via reverse immunology – Highlighting our Publications

T cell responses contribute to immunity against many intracellular infections. There is, for example, strong evidence that major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) play an essential role in mediating immunity to East Coast fever (ECF), a fatal lymphoproliferative disease of cattle prevalent in sub-Saharan Africa and caused by Theileria parva. o … Continue reading

AHH / CBPP / Disease Control / Event / Project / Research / Vaccines

Research to control lung plague (CBPP) gets a major boost: New project launched

On 2 July 2012 a new project was launched to develop a novel subunit cattle vaccine for the control of contagious bovine pleuropneumonia (CBPP), known as lung plague. This was announced by Canada’s International Development Research Centre (IDRC) and the Canadian International Development Agency (CIDA) under the Canadian International Food Security Research Fund (CIFSRF). ‘CIFSRF, … Continue reading

AHH / Disease Control / Vaccines

Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting – Highlighting our Publications

Commercial vaccines based on the tick gut protein Bm86 have been successful in controlling the one-host tick Rhipicephalus (Boophilus) microplus and provide heterologous protection against certain other non-target ixodid tick species. This cross protection, however, does not extend to the three-host tick R. appendiculatus, the vector of the protozoan parasite Theileria parva. When transmitted to … Continue reading

AHH / Disease Control / East Africa / Event / Southern Africa / Vaccines

Scientists discuss current knowledge and research approaches that could lead to a next generation ECF vaccine

The next generation vaccine for East Coast fever (EFC), an important cattle disease was the discussion agenda in a 2.5 day workshop organized by the International Livestock Research Institute (ILRI), United States Department of Agriculture Agricultural-Research Service (USDA-ARS) and Global Alliance for Livestock Veterinary Medicines (GALVmed) on April 16-18. Stakeholders from Nairobi-ILRI, USA, UK, Belgium, … Continue reading

AHH / Disease Control / Kenya / Vaccines

Study shows promising new avenues to develop a product that could help in the control of Theileriosis

A recent study on ‘Identification of virulence factors of Theileria parva’ has confirmed the existence of a low virulent strain and identified the mechanism that was at the basis of this low virulence, showing some promising new avenues to develop a product that could help in the control of Theileriosis. This low virulent strain, Chitongo … Continue reading